Publications

2024

Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1^-/-Ldlr^-/-mice

Porteiro B, Roscam Abbing RLP, In Het Panhuis W, de Waart DR, Duijst S, Bolt I, Vogels EW, Levels JHM, Bosmans LA, Vos WG, Oude Elferink RPJ, Lutgens E, van de Graaf SFJ.J

Lipid Res. 2024 Aug;65(8):100594. doi: 10.1016/j.jlr.2024.100594. Epub 2024 Jul 14.PMID:39009243

Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1^-/-Ldlr^-/-mice

Maladaptive regeneration and metabolic dysfunction associated steatotic liver disease: Common mechanisms and potential therapeutic targets

Wu D, van de Graaf SFJ

Biochem Pharmacol. 2024 Sep;227:116437. doi: 10.1016/j.bcp.2024.116437. Epub 2024 Jul 16.PMID:39025410

Maladaptive regeneration and metabolic dysfunction associated steatotic liver disease: Common mechanisms and potential therapeutic targets.

Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids

Remco Kersten ^# , David C Trampert ^# , Lowiek M Hubers, Dagmar Tolenaars, Harmjan R Vos, Stan F J van de Graaf, Ulrich Beuers

Front Immunol. 2024 Jan 25:14:1251134. doi: 10.3389/fimmu.2023.1251134. eCollection 2023.

Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids - PubMed (nih.gov)

The phospholipid flippase ATP8B1 is involved in the pathogenesis of Ulcerative Colitis via establishment of intestinal barrier function

Pim J Koelink , Valentina E Gómez-Mellado , Suzanne Duijst , Manon van Roest , Sander Meisner , Kam S Ho-Mok , Sabrina Frank , Babette S Appelman , Lysbeth Ten Bloemendaal, Georg F Vogel , Stan F J van de Graaf , Piter J Bosma , Ronald P J Oude Elferink , Manon E Wildenberg , Coen C Paulusma

J Crohns Colitis. 2024 Feb 16:jjae024. doi: 10.1093/ecco-jcc/jjae024. Online ahead of print.

The phospholipid flippase ATP8B1 is involved in the pathogenesis of Ulcerative Colitis via establishment of intestinal barrier function - PubMed (nih.gov)

Targeting bile salt homeostasis in biliary diseases

David C Trampert, Roni F Kunst, Stan F J van de Graaf 

Curr Opin Gastroenterol. 2024 Mar 1;40(2):62-69. doi: 10.1097/MOG.0000000000000997. Epub 2024 Jan 10.

Targeting bile salt homeostasis in biliary diseases - PubMed (nih.gov)

Bile salt signaling and bile salt-based therapies in cardiometabolic disease

Claire C J Groenen ^# , Thuc-Anh Nguyen ^# , Coen C Paulusma , Stan F J van de Graaf

Clin Sci (Lond). 2024 Jan 10;138(1):1-21. doi: 10.1042/CS20230934.

Bile salt signaling and bile salt-based therapies in cardiometabolic disease - PubMed (nih.gov)

Laminin 511-E8, an autoantigen in IgG4-related cholangitis, contributes to cholangiocyte protection

Trampert DC, Kersten R, Tolenaars D, Jongejan A,van de Graaf SFJ, Beuers U.

JHEP Rep. 2024 Jan 23;6(4):101015. doi: 10.1016/j.jhepr.2024.101015. eCollection 2024 Apr.PMID:38524667

Laminin 511-E8, an autoantigen in IgG4-related cholangitis, contributes to cholangiocyte protection

The Phospholipid Flippase ATP8B1 is Involved in the Pathogenesis of Ulcerative Colitis via Establishment of Intestinal Barrier Function

Koelink PJ, Gómez-Mellado VE, Duijst S, van Roest M, Meisner S, Ho-Mok KS, Frank S, Appelman BS, Bloemendaal LT, Vogel GF,van de Graaf SFJ, Bosma PJ, Oude Elferink RPJ, Wildenberg ME, Paulusma CC.J

Crohns Colitis. 2024 Aug 6;18(7):1134-1146. doi: 10.1093/ecco-jcc/jjae024.PMID:383668

The Phospholipid Flippase ATP8B1 is Involved in the Pathogenesis of Ulcerative Colitis via Establishment of Intestinal Barrier Function

2023

Combined inhibition of bile salt synthesis and intestinal uptake reduces cholestatic liver damage and colonic bile salts in mice

Roni F Kunst , Isabelle Bolt , Rychon D J van Dasselaar , Bart A Nijmeijer , Ulrich Beuers , Ronald P J Oude Elferink , Stan F J van de Graaf

JHEP Rep . 2023 Sep 25;6(1):100917. doi: 10.1016/j.jhepr.2023.100917. eCollection 2024 Jan.

Combined inhibition of bile salt synthesis and intestinal uptake reduces cholestatic liver damage and colonic bile salts in mice - PubMed (nih.gov)

IgG4-related cholangitis - a mimicker of fibrosing and malignant cholangiopathies

Remco Kersten  David C Trampert, Toni Herta, Lowiek M Hubers, Lucas J Maillette de Buy Wenniger, Joanne Verheij, Stan F J van de Graaf, Ulrich Beuers

J Hepato. 2023 Dec;79(6):1502-1523.doi: 10.1016/j.jhep.2023.08.005. Epub 2023 Aug 18.

IgG4-related cholangitis - a mimicker of fibrosing and malignant cholangiopathies - PubMed (nih.gov)

Bile Salts by the Back Road

Ronald P J Oude Elferink Stan F J Van De Graaf

Cell Mol Gastroenterol Hepatol. 2023;16(2):319-320. doi: 10.1016/j.jcmgh.2023.05.005. Epub 2023 May 24.

Bile Salts by the Back Road - PubMed (nih.gov)

Intestinal Bacteremia After Liver Transplantation Is a Risk Factor for Recurrence of Primary Sclerosing Cholangitis

Ruslan A Mammadov , Jasmijn W Selten, Henk P Roest, Cornelia J Verhoeven , Luca Maroni, Sandra I Bril, Dagmar Tolenaars, Pravesh S Gadjradj, Stan F J van de Graaf  Ronald P J Oude Elferink, Jaap Kwekkeboom, Herold J Metselaar, Maikel P Peppelenbosch, Ulrich Beuers, Jan N M IJzermans, Luc J W van der Laan

Intestinal Bacteremia After Liver Transplantation Is a Risk Factor for Recurrence of Primary Sclerosing Cholangitis - PubMed (nih.gov)

2022

Role of the IgG4-related cholangitis autoantigen annexin A11 in cholangiocyte protection

Herta T, Kersten R, Chang JC, Hubers L, Go S, Tolenaars D, Paulusma CC, Nathanson MH, Elferink RO,van de Graaf SFJ, Beuers U

J Hepatol. 2022 Feb;76(2):319-331. doi: 10.1016/j.jhep.2021.10.009. Epub 2021 Oct 27.PMID:34718050

Role of the IgG4-related cholangitis autoantigen annexin A11 in cholangiocyte protection - PubMed (nih.gov)

Amino acid metabolism, transport and signalling in the liver revisited

Paulusma CC, Lamers WH, Broer S,van de Graaf SFJ.

Biochem Pharmacol. 2022 Jul;201:115074. doi: 10.1016/j.bcp.2022.115074. Epub 2022 May 11.PMID:35568239

Amino acid metabolism, transport and signalling in the liver revisited - PubMed (nih.gov)

Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice

Kunst RF, de Waart DR, Wolters F, Duijst S, Vogels EW, Bolt I, Verheij J, Beuers U, Oude Elferink RPJ,van de Graaf SFJ

JHEP Rep. 2022 Aug 27;4(11):100573. doi: 10.1016/j.jhepr.2022.100573. eCollection 2022 Nov.PMID:36160754

Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice - PubMed (nih.gov)

Differential and organ-specific functions of organic solute transporter α and β in experimental cholestasis

van de Wiel SMW, Porteiro B, Belt SC, Vogels EWM, Bolt I, Vermeulen JLM, de Waart DR, Verheij J, Muncan V, Oude Elferink RPJ,van de Graaf SFJ.

Differential and organ-specific functions of organic solute transporter α and β in experimental cholestasis - PubMed (nih.gov)

JHEP Rep.2022 Mar 5;4(5):100463.doi: 10.1016/j.jhepr.2022.100463.

2021

Erratum to: "Hepatobiliary acid-base homeostasis: Insights from analogous secretory epithelia" (J Hepatol 2021; 74: 428-441).

Trampert DC, van de Graaf SFJ, Jongejan A, Oude Elferink RPJ, Beuers U.

J Hepatol. 2021 Aug;75(2):497. doi: 10.1016/j.jhep.2021.05.002. Epub 2021 May 13.PMID: 33991636

Inhibition of autotaxin by bile salts and bile salt-like molecules increases its expression by feedback regulation.

Langedijk JAGM, Tolenaars D, Bolier R, Lee YT, Meurs A, Williamson C, Adorini L, van de Graaf SFJ, Beuers U, Elferink RO.

Biochim Biophys Acta Mol Basis Dis. 2021 Nov 1;1867(11):166239. doi: 10.1016/j.bbadis.2021.166239. Epub 2021 Aug 10.PMID: 34389475 

Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions.

Zaufel A, van de Wiel SMW, Yin L, Fauler G, Chien D, Dong X, Gilmer JF, Truong JK, Dawson PA, van de Graaf SFJ, Fickert P, Moustafa T.

Biochim Biophys Acta Mol Basis Dis. 2021 Aug 1;1867(8):166153. doi: 10.1016/j.bbadis.2021.166153. Epub 2021 Apr 22.PMID: 33895309 

Applicability of different cell line-derived dendritic cell-like cells in autophagy research.

Prins MMC, van Roest M, Vermeulen JLM, Tjabringa GS, van de Graaf SFJ, Koelink PJ, Wildenberg ME.

J Immunol Methods. 2021 Oct;497:113106. doi: 10.1016/j.jim.2021.113106. Epub 2021 Jul 26.PMID: 34324891

 Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology.

Kunst RF, Verkade HJ, Oude Elferink RPJ, van de Graaf SFJ.

Hepatology. 2021 Jun;73(6):2577-2585. doi: 10.1002/hep.31651. Epub 2021 May 24.PMID: 33222321 

Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP.

Appelman MD, Wettengel JM, Protzer U, Oude Elferink RPJ, van de Graaf SFJ

Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158960. doi: 10.1016/j.bbalip.2021.158960. Epub 2021 Apr 29.PMID: 33932583 

Hepatobiliary acid-base homeostasis: Insights from analogous secretory epithelia

Trampert DC, van de Graaf SFJ, Jongejan A, Oude Elferink RPJ, Beuers U.
J Hepatol. 2021 Feb;74(2):428-441. doi: 10.1016/j.jhep.2020.10.010.  PMID: 33342564.

2020

Targeting the four pillars of enterohepatic bile salt cycling; lessons from genetics and pharmacology.

Kunst RF, Verkade HJ, Oude Elferink RPJ, van de Graaf SFJ. 

Hepatology. 2020 doi: 10.1002/hep.31651. PMID: 33222321.

An Exon-Specific Small Nuclear U1 RNA (ExSpeU1) Improves Hepatic OTC Expression in a Splicing-Defective
spf/ash Mouse Model of Ornithine Transcarbamylase Deficiency.

Balestra D, Ferrarese M, Lombardi S, Ziliotto N, Branchini A, Petersen N, Bosma P, Pinotti M, van de Graaf SFJ.

Int J Mol Sci. 2020 ;21(22):8735. doi: 10.3390/ijms21228735. PMID: 33228018

From fatty hepatocytes to impaired bile flow: Matching model systems for liver biology and
disease.Kunst RF, Niemeijer M, van der Laan LJW, Spee B, van de Graaf SFJ.

Biochem Pharmacol. 2020;180:114173. doi: 10.1016/j.bcp.2020.114173.PMID: 32717228.

Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity.

Donkers JM, Roscam Abbing RLP, van Weeghel M, Levels JHM, Boelen A, Schinkel
AH, Oude Elferink RPJ, van de Graaf SFJ. 
Cell Mol Gastroenterol Hepatol. 2020;10(3):451-466. doi:
10.1016/j.jcmgh.2020.04.009. Epub 2020 Apr 21. PMID: 32330730

Blocking sodium-taurocholate cotransporting polypeptide stimulates biliary cholesterol and phospholipid secretion.

Roscam Abbing RLP, Slijepcevic D, Donkers JM, Havinga R, Duijst S, Paulusma CC, Kuiper J, Kuipers F, Groen AK, Oude Elferink RPJ and Van de Graaf SFJ.

Hepatology, 2020 Jan;71(1):247-258. PMID: 31136002

The Lipid Raft Component Stomatin Interacts with the Na⁺ Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake.

Appelman MD, Robin MJD, Vogels EWM, Wolzak C, Vos WG, Vos HR, Van Es RM, Burgering BMT, Van de Graaf SFJ.

Cells. 2020 Apr 16;9(4):986. doi: 10.3390/cells9040986.PMID: 32316189 

A Compensatory U1snRNA Partially Rescues FAH Splicing and Protein Expression in a Splicing-Defective Mouse Model of Tyrosinemia Type I.

Balestra D, Scalet D, Ferrarese M, Lombardi S, Ziliotto N, C Croes C, Petersen N, Bosma P, Riccardi F, Pagani F, Pinotti M, van de Graaf SFJ.

Int J Mol Sci. 2020 Mar 20;21(6):2136. doi: 10.3390/ijms21062136. PMID: 32244944

2019

FDA-drug screening identifies deptropine inhibiting hepatitis E virus involving the NF-κB-RIPK1-caspase axis

Qu C, Li Y, Li Y, Yu P, Li P, Donkers JM, Van de Graaf SFJ, de Man RA, Peppelenbosch MP, Pan Q.

Antiviral Res. 2019 Oct;170:104588. PMID: 31415805

Mechanistic insights to the inhibition of NTCP by Myrcludex B

Joanne M. Donkers, Monique D. Appelman and Stan F.J. van de Graaf.

Journal Of Hepatology Reports, 2019 Aug 1;1(4):278-285. PMID: 32039379

NTCP deficiency in mice protects against obesity and hepatosteatosis

Donkers JM, Kooijman S, Slijepcevic D, Kunst R, Roscam Abbing RLP, Haazen L, De Waart DR, Levels JHM, Schoonjans K, Rensen PCN, Oude Elferink RPJ and Van de Graaf SFJ.

JCI Insight, 2019. doi: 10.1172/jci.insight.127197. PMID: 31237863

Developments in bile salt based therapies: A critical overview.

Donkers JM, Roscam Abbing RLP, Van de Graaf SFJ. PMID: 30582898

Biochemical Pharmacology. 2019 Mar;161:1-13

Identification of FDA-approved drugs targeting the Farnesoid X Receptor

Van de Wiel SMW, Bijsmans ITGW, Van Mil SWC, Van de Graaf SFJ.

Sci Rep. 2019 Feb 18;9(1):2193. PMID: 30778102

2018

Calnexin depletion by ER-stress during cholestasis inhibits the Na⁺-taurocholate Cotransporting Polypeptide (NTCP)

Robin MJD, Monique D. Appelman MD, Vos HR, Van Es RM, Paton JC, Paton AW, Burgering B, Fickert P, Heijmans J, Van de Graaf SFJ. Hepatology Communications, 2018 Oct 23;2(12):1550-1566. PMID: 30556041

The case for combining treatments for primary sclerosing cholangitis

Roscam Abbing RLP, de Lannoy LM, van de Graaf SFJ.

Lancet Gastroenterol Hepatol. 2018 Aug;3(8):526-528. PMID: 30047442

Na+ -taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice

Slijepcevic D, Roscam Abbing RLP, Fuchs CD, Haazen LCM, Beuers U, Trauner M, Oude Elferink RPJ, Van de Graaf SFJ.

Hepatology. 2018, 68: 3, p.1057-1069. PMID: 29572910

Bioengineered bile ducts recapitulate key cholangiocyte functions

Chen C, Jochems PGM, Salz L, Schneeberger K, Penning LC, van de Graaf SFJ, Beuers U, Clevers H, Geijsen N, Masereeuw R, Spee B.  Biofabrication. 2018 Jun 12;10(3):034103. PMID: 29848792

The somatic FAH C.1061C>A change counteracts the frequent FAH c.1062+5G>A mutation and permits U1snRNA-based splicing correction.

Scalet D, Sacchetto C, Bernardi F, Pinotti M, Van de Graaf SFJ, Balestra D.

J Hum Genet. 2018 May;63(5):683-686. PMID: 29497141

Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease

Hubers LM, Vos H, Schuurman AR, Erken R, Oude Elferink RP, Burgering B, van de Graaf SFJ*, Beuers U*.

Gut. 2018 Apr;67(4):728-735. PMID: 28765476

On the role of IgG4 in inflammatory conditions: lessons for IgG4-related disease

Trampert DC, Hubers LM, Van de Graaf SF, Beuers U.

BBA - Molecular Basis of Disease, 2018 Apr;1864(4 Pt B):1401-1409. PMID: 28782655

The NTCP - inhibitor myrcludex B: Effects on bile acid disposition and tenofovir pharmacokinetics

Blank A, Eidam A, Haag M, Hohmann N, Burhenne J, Schwab M, Van de Graaf S, Meyer MR, Maurer HH, Meier K, Weiss J, Bruckner T, Alexandrov A, Urban S, Mikus G, Haefeli WE.

Clin Pharmacol Ther. 2018 Feb;103(2):341-348. PMID: 28543042

2017

Role of the Bile Acid Transporter SLC10A1 in Liver Targeting of the Lipid-Lowering Thyroid Hormone Analog Eprotirome

Kersseboom S, van Gucht ALM, van Mullem A, Brigante G, Farina S, Carlsson B, Donkers JM, van de Graaf SFJ, Peeters RP, Visser TJ.

Endocrinology. 2017 Oct 1;158(10):3307-3318. PMID: 28938430

Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo

van Dijk R, Aronson SJ, de Waart DR, van de Graaf SF, Duijst S, Seppen J, Elferink RO, Beuers U, Bosma PJ.

Sci Rep. 2017 May 10;7(1):1646. PMID: 28490767

Current and future therapies for inherited cholestatic liver diseases

van der Woerd WL, Houwen RH, van de Graaf SF.

World J Gastroenterol. 2017 Feb 7;23(5):763-775. doi: 10.3748/wjg.v23.i5.763. Review. PMID: 28223721  /  PMCID: 2596193

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection

Appelman MD, Chakraborty A, Protzer U, McKeating JA, van de Graaf SF.

PLoS One. 2017 Jan 26;12(1):e0170419. doi: 10.1371/journal.pone.0170419.  PMID: 28125599

Knockout of the Primary Sclerosing Cholangitis-Risk Gene Fut2 Causes Liver Disease in Mice

Maroni L, Hohenester SD, van de Graaf SF, Tolenaars D, van Lienden K, Verheij J, Marzioni M, Karlsen TH, Oude Elferink RP, Beuers U.

Hepatology. 2017 Jan 5. doi: 10.1002/hep.29029. [Epub ahead of print] PMID: 28056490

Bile Acid Uptake Transporters as Targets for Therapy

Slijepcevic D, van de Graaf SF.

Dig Dis. 2017;35(3):251-258. doi: 10.1159/000450983.  PMID: 28249291

Hepatic uptake of conjugated bile acids is mediated by both NTCP and OATPs and modulated by intestinal sensing of plasma bile acid levels in mice

Slijepcevic D, Roscam Abbing RLP, Katafuchi T, Blank A, Donkers JM, van Hoppe S, de Waart DR, Tolenaars D, van der Meer JHM, Wildenberg M, Beuers U, Oude Elferink RPJ, Schinkel AH, Van de Graaf SF.

Hepatology. 2017 Nov;66(5):1631-1643  (see also Hepatology. 2018 Mar;67(3):1185-1186). PMID: 28498614

Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

Joanne M. Donkers, Benno Zehnder, Gerard J. P. van Westen, Mark J. Kwakkenbos,Adriaan P. IJzerman, Ronald P. J. Oude Elferink, Ulrich Beuers, Stephan Urban & Stan F. J. van de Graaf

Scientific Reports | 7: 15307 | DOI:10.1038/s41598-017-15338-0. PMID: 29127322

Intestinal FXR activation by pharmacological inhibition of the organic solute transporter α-β

Sandra M.W. van de Wiel, D. Rudi de Waart, Ronald P.J. Oude Elferink and Stan F.J. van de Graaf.

Cellular and Molecular Gastroenterology and Hepatology, 2017 Nov 28;5(3):223-237. PMID: 29675448 / PMCID: 5904037

2016

Immunoglobulin G4+ B-cell receptor clones distinguish immunoglobulin G 4-related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies

Doorenspleet ME, Hubers LM, Culver EL, Maillette de Buy Wenniger LJ, Klarenbeek PL, Chapman RW, Baas F, van de Graaf SF, Verheij J, van Gulik TM, Barnes E, Beuers U, de Vries N.

Hepatology. 2016;64(2):501-7. doi: 10.1002/hep.28568. PMID: 27015613

Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis

Van der Woerd WL, Wichers CG, Vestergaard AL, Andersen JP, Paulusma CC, Houwen RH, van de Graaf SF.

J Hepatol. 2016;64(6):1339-47. doi: 10.1016/j.jhep.2016.02.001. PMID: 26879107

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor

Sandra Van de Wiel, Maarten Merkx and Stan van de Graaf

Journal of Visualized Experiments, JoVE (http://www.jove.com/video/53659)

2015

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.

Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL.

J Cell Biol. 2015 Sep 28;210(7):1055-63. PMID: 26416959

Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in Na(+) -taurocholate cotransporting polypeptide knockout mice

Slijepcevic D, Kaufman C, Wichers CG, Gilglioni EH, Lempp FA, Duijst S, de Waart DR, Oude Elferink RP, Mier W, Stieger B, Beuers U, Urban S, Van de Graaf SF.

Hepatology. 2015 Jul;62(1):207-19] PubMed PMID: 25641256.

Analysis of aberrant pre-messenger RNA splicing resulting from mutations in ATP8B1 and efficient in vitro rescue by adapted U1 small nuclear RNA

Van der Woerd WL, Mulder J, Pagani F, Beuers U, Houwen RH, Van de Graaf SF.

Hepatology. 2015 Apr;61(4):1382-91. doi: 10.1002/hep.27620. Epub 2015 Feb 23. PubMed PMID: 25421123.

IgG4-Associated Cholangitis: A Comprehensive Review

Hubers LM, Maillette de Buy Wenniger LJ, Doorenspleet ME, Klarenbeek PL, Verheij J, Rauws EA, Van Gulik TM, Oude Elferink RP, Van de Graaf SF, de Vries N, Beuers U.

Clin Rev Allergy Immunol. 2015 Jun;48(2-3):198-206. doi: 10.1007/s12016-014-8430-2. PubMed PMID: 24958363

Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease-a comprehensive review

Maroni L, Van de Graaf SF, Hohenester SD, Oude Elferink RP, Beuers U. .

Clin Rev Allergy Immunol. 2015 Jun;48(2-3):182-91. doi: 10.1007/s12016-014-8423-1. PubMed PMID: 24828903.

2014

Quantifying stickiness: thermodynamic characterization of intramolecular domain interactions to guide the design of förster resonance energy transfer sensors

Lindenburg LH, Malisauskas M, Sips T, Van Oppen L, Wijnands SP, Van de Graaf SF, Merkx M.

Biochemistry. 2014 Oct 14;53(40):6370-81. doi: 10.1021/bi500433j. Epub 2014 Sep 26. PubMed PMID: 25216081

IgG4-associated cholangitis

Beuers U, Maillette de Buy Wenniger LJ, Doorenspleet M, Hubers L, Verheij J, Van Gulik T, Van de Graaf SF, de Vries N. 

Dig Dis. 2014;32(5):605-8. doi: 10.1159/000360513. Epub 2014 Jul 14. Review. PubMed PMID: 25034294

Autophagy - another piece of the puzzle towards understanding primary biliary cirrhosis?

Van de Graaf S, Beuers U.

Liver Int. 2014 Apr;34(4):481-3. doi: 10.1111/liv.12357. No abstract available.  PMID:  24612169

2013

Mutational analysis of ATP8B1 in patients with chronic pancreatitis

Van der Woerd WL, Van Haaften-Visser DY, Van de Graaf SF, Férec C, Masson E, Stapelbroek JM, Bugert P, Witt H, Houwen RH.

PLoS One. 2013 Nov 19;8(11):e80553. doi: 10.1371/journal.pone.0080553. eCollection 2013. PubMed PMID: 24260417; PubMed Central PMCID: PMC3834041.

Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60

Gao Y, Koppen A, Rakhshandehroo M, Tasdelen I, Van de Graaf SF, Van Loosdregt  J, Van Beekum O, Hamers N, Van Leenen D, Berkers CR, Berger R, Holstege FC, Coffer PJ, Brenkman AB, Ovaa H, Kalkhoven E.

Nat Commun. 2013;4:2656. doi: 10.1038/ncomms3656. PubMed PMID: 24141283

Monitoring bile acid transport in single living cells using a genetically encoded Förster resonance energy transfer sensor

Van der Velden LM, Golynskiy MV, Bijsmans IT, Van Mil SW, Klomp LW, Merkx M, Van de Graaf SF.

Hepatology. 2013 Feb;57(2):740-52. doi: 10.1002/hep.26012. Epub 2013 Jan 8. PubMed PMID: 22899095

2012

Natural killer T cells in adipose tissue prevent insulin resistance

Schipper HS, Rakhshandehroo M, Van de Graaf SF, Venken K, Koppen A, Stienstra R, Prop S, Meerding J, Hamers N, Besra G, Boon L, Nieuwenhuis EE, Elewaut D, Prakken B, Kersten S, Boes M, Kalkhoven E.

J Clin Invest. 2012 Sep;122(9):3343-54. doi: 10.1172/JCI62739. Epub 2012 Aug 6. PubMed PMID: 22863618; PubMed Central PMCID:

PMC3428087.

Homo- and hetero-dimeric architecture of the human liver Na⁺-dependent taurocholate co-transporting protein

Bijsmans IT, Bouwmeester RA, Geyer J, Faber KN, Van de Graaf SF.

Biochem J. 2012 Feb 1;441(3):1007-15. doi: 10.1042/BJ20111234. PubMed PMID: 22029531

2010

Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy

Van der Woerd WL, Van Mil SW, Stapelbroek JM, Klomp LW, Van de Graaf SF, Houwen RH. 

Best Pract Res Clin Gastroenterol. 2010 Oct;24(5):541-53. doi: 10.1016/j.bpg.2010.07.010. Review. PubMed PMID: 20955958

Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases

Van der Velden LM, Wichers CG, Van Breevoort AE, Coleman JA, Molday RS, Berger R, Klomp LW, Van de Graaf SF.

J Biol Chem. 2010 Dec 17;285(51):40088-96. doi: 10.1074/jbc.M110.139006. Epub 2010 Oct 14. PubMed PMID: 20947505; PubMed Central PMCID: PMC3000991.

Biochemical and cellular functions of P4 ATPases

Van der Velden LM, Van de Graaf SF, Klomp LW.

Biochem J. 2010 Oct 1;431(1):1-11. doi: 10.1042/BJ20100644. Review. PubMed PMID: 20836764

Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate

Van der Velden LM, Stapelbroek JM, Krieger E, Van den Berghe PV, Berger R, Verhulst PM, Holthuis JC, Houwen RH, Klomp LW, Van de Graaf SF.

Hepatology. 2010 Jan;51(1):286-96. doi: 10.1002/hep.23268. PubMed PMID: 19918981

2009

Reduced expression of ATP7B affected by Wilson disease-causing mutations is rescued by pharmacological folding chaperones 4-phenylbutyrate and curcumin

Van den Berghe PV, Stapelbroek JM, Krieger E, de Bie P, Van de Graaf SF, de Groot RE, Van Beurden E, Spijker E, Houwen RH, Berger R, Klomp LW.

Hepatology. 2009 Dec;50(6):1783-95. doi: 10.1002/hep.23209. PubMed PMID: 19937698

Conditional fast expression and function of multimeric TRPV5 channels using Shield-1

Schoeber JP, Van de Graaf SF, Lee KP, Wittgen HG, Hoenderop JG, Bindels RJ.

Am J Physiol Renal Physiol. 2009 Jan;296(1):F204-11. doi: 10.1152/ajprenal.90473.2008. Epub 2008 Oct 8. PubMed PMID: 18842822

2008 and before

Van de Graaf SF, Rescher U, Hoenderop JG, Verkaart S, Bindels RJ, Gerke V. TRPV5 is internalized via clathrin-dependent endocytosis to enter a Ca2+-controlled recycling pathway. J Biol Chem. 2008 Feb 15;283(7):4077-86. Epub  2007 Dec 12. PubMed PMID: 18077461.

Van de Graaf SF, Bindels RJ, Hoenderop JG. Physiology of epithelial Ca2+ and  Mg2+ transport. Rev Physiol Biochem Pharmacol. 2007;158:77-160. Review. PubMed PMID: 17729442.

Van de Graaf SF, Hoenderop JG, Bindels RJ. Regulation of TRPV5 and TRPV6 by associated proteins. Am J Physiol Renal Physiol. 2006 Jun;290(6):F1295-302. Review. PubMed PMID: 16682485.

Van de Graaf SF, Hoenderop JG, Van der Kemp AW, Gisler SM, Bindels RJ. Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine-and kidney-enriched PDZ protein NHERF4. Pflugers Arch. 2006 Jul;452(4):407-17. Epub 2006 Mar 25. PubMed PMID: 16565876.

Van de Graaf SF, Van der Kemp AW, Van den Berg D, Van Oorschot M, HoenderopJG, Bindels RJ. Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity. J Am Soc Nephrol. 2006 Jan;17(1):26-30. PubMed PMID: 16380433.

Van de Graaf SF, Chang Q, Mensenkamp AR, Hoenderop JG, Bindels RJ. Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane. Mol Cell Biol. 2006 Jan;26(1):303-12. PubMed PMID: 16354700; PubMed Central PMCID: PMC1317621.

den Dekker E, Schoeber J, Topala CN, Van de Graaf SF, Hoenderop JG, Bindels RJ. Characterization of a Madin-Darby canine kidney cell line stably expressing TRPV5. Pflugers Arch. 2005 Jul;450(4):236-44. Epub 2005 May 28. PubMed PMID: 15924239.

Palmada M, Poppendieck S, Embark HM, Van de Graaf SF, Boehmer C, Bindels RJ, Lang F. Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1. Cell Physiol Biochem. 2005;15(1-4):175-82. PubMed PMID: 15665527.

Chang Q, Gyftogianni E, Van de Graaf SF, Hoefs S, Weidema FA, Bindels RJ, Hoenderop JG. Molecular determinants in TRPV5 channel assembly. J Biol Chem. 2004 Dec 24;279(52):54304-11. Epub 2004 Oct 15. PubMed PMID: 15489237.

Embark HM, Setiawan I, Poppendieck S, Van de Graaf SF, Boehmer C, Palmada M, Wieder T, Gerstberger R, Cohen P, Yun CC, Bindels RJ, Lang F. Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes. Cell Physiol Biochem. 2004;14(4-6):203-12. PubMed PMID: 15319523.

Van de Graaf SF, Boullart I, Hoenderop JG, Bindels RJ. Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):303-8. Review. PubMed PMID: 15225790.

Van de Graaf SF, Hoenderop JG, Gkika D, Lamers D, Prenen J, Rescher U, Gerke  V, Staub O, Nilius B, Bindels RJ. Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J. 2003 Apr 1;22(7):1478-87. PubMed PMID: 12660155; PubMed Central PMCID: PMC152906.

Danahay H, Withey L, Poll CT, Van de Graaf SF, Bridges RJ. Protease-activated receptor-2-mediated inhibition of ion transport in human bronchial epithelial cells. Am J Physiol Cell Physiol. 2001 Jun;280(6):C1455-64. PubMed PMID:11350741.

Hoenderop JG, Van der Kemp AW, Hartog A, Van de Graaf SF, Van Os CH, Willems PH, Bindels RJ. Molecular identification of the apical Ca2+ channel in 1,25-dihydroxyvitamin D3-responsive epithelia. J Biol Chem. 1999 Mar26;274(13):8375-8. PubMed PMID: 10085067.