small.png?etag=%22545c-5e8edd4e%22&sourceContentType=image%2Fpng&ignoreAspectRatio&resize=300%2B54)
Van de Graaf Lab
Student projects
We have intership positions for Msc and Bsc students:
Workplan 1: Supervisor Roni Kunst PhD student
In the Tytgat Institute, biomedical research on the field of hepatology is performed. In this project we study bile formation and cholestasis (impaired bile flow). We test novel therapeuticaly approaches in pre-clinical studies (in vitro, ex-vivo).
Techniques: Q-PCR, Western blotting, immuno-histochemistry, histology.
Workplan 2: Supervisor Tulasi Yadati, post-doc and Anh Nguyen, PhD student
In the Tytgat Institute, biomedical research on the field of hepatology is performed. Currently, we are investigating the immunosuppressive effects of bile acids in mice and in vitro. We also have projects that focus on the impact of bile acid signaling on Non-alcoholic fattty liver disease. The elective student will perform and assist in mouse experiments in vivo as well as advanced cell culture experiments with immune cells.
He/she will become skilled in:
- Cell culture, FACS analysis, cytokine measurements and experimental techniques of biochemistry and molecular biology.
- Screening assays to test novelG-protein coupled receptors for bile salts, and possibly eventually in vivo binding studies.