Publications

Publications

 

2018

 

Na+ -taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice.

Slijepcevic D, Roscam Abbing RLP, Fuchs CD, Haazen LCM, Beuers U, Trauner M, Oude Elferink RPJ, Van de Graaf SFJ. Hepatology. 2018, in press

 

The somatic FAH C.1061C>A change counteracts the frequent FAH c.1062+5G>A mutation and permits U1snRNA-based splicing correction.

Scalet D, Sacchetto C, Bernardi F, Pinotti M, Van de Graaf SFJ, Balestra D. J Hum Genet. 2018 May;63(5):683-686

 

Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease

Hubers LM, Vos H, Schuurman AR, Erken R, Oude Elferink RP, Burgering B, van de Graaf SFJ*, Beuers U*. Gut. 2018 Apr;67(4):728-735

 

On the role of IgG4 in inflammatory conditions: lessons for IgG4-related disease.

Trampert DC, Hubers LM, Van de Graaf SF, Beuers U. BBA - Molecular Basis of Disease, 2018 Apr;1864(4 Pt B):1401-1409

 

The NTCP - inhibitor myrcludex B: Effects on bile acid disposition and tenofovir pharmacokinetics.

Blank A, Eidam A, Haag M, Hohmann N, Burhenne J, Schwab M, Van de Graaf S, Meyer MR, Maurer HH, Meier K, Weiss J, Bruckner T, Alexandrov A, Urban S, Mikus G, Haefeli WE. Clin Pharmacol Ther. 2018 Feb;103(2):341-348

 

 

 

2017

 

Role of the Bile Acid Transporter SLC10A1 in Liver Targeting of the Lipid-Lowering Thyroid Hormone Analog Eprotirome.

Kersseboom S, van Gucht ALM, van Mullem A, Brigante G, Farina S, Carlsson B, Donkers JM, van de Graaf SFJ, Peeters RP, Visser TJ.

Endocrinology. 2017 Oct 1;158(10):3307-3318.

PMID: 28938430

 

Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo.

van Dijk R, Aronson SJ, de Waart DR, van de Graaf SF, Duijst S, Seppen J, Elferink RO, Beuers U, Bosma PJ.

Sci Rep. 2017 May 10;7(1):1646

 

Current and future therapies for inherited cholestatic liver diseases.

van der Woerd WL, Houwen RH, van de Graaf SF.

World J Gastroenterol. 2017 Feb 7;23(5):763-775. doi: 10.3748/wjg.v23.i5.763. Review.

PMID: 28223721

 

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection.

Appelman MD, Chakraborty A, Protzer U, McKeating JA, van de Graaf SF.

PLoS One. 2017 Jan 26;12(1):e0170419. doi: 10.1371/journal.pone.0170419.

PMID: 28125599

 

Knockout of the Primary Sclerosing Cholangitis-Risk Gene Fut2 Causes Liver Disease in Mice.

Maroni L, Hohenester SD, van de Graaf SF, Tolenaars D, van Lienden K, Verheij J, Marzioni M, Karlsen TH, Oude Elferink RP, Beuers U.

Hepatology. 2017 Jan 5. doi: 10.1002/hep.29029. [Epub ahead of print]

PMID: 28056490

 

Bile Acid Uptake Transporters as Targets for Therapy.

Slijepcevic D, van de Graaf SF.

Dig Dis. 2017;35(3):251-258. doi: 10.1159/000450983.

PMID: 28249291

 

Hepatic uptake of conjugated bile acids is mediated by both NTCP and OATPs and modulated by intestinal sensing of plasma bile acid levels in mice.

Slijepcevic D, Roscam Abbing RLP, Katafuchi T, Blank A, Donkers JM, van Hoppe S, de Waart DR, Tolenaars D, van der Meer JHM, Wildenberg M, Beuers U, Oude Elferink RPJ, Schinkel AH, Van de Graaf SF. Hepatology. 2017 Nov;66(5):1631-1643 (see also Hepatology. 2018 Mar;67(3):1185-1186)

 

Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

Joanne M. Donkers, Benno Zehnder, Gerard J. P. van Westen, Mark J. Kwakkenbos,Adriaan P. IJzerman, Ronald P. J. Oude Elferink, Ulrich Beuers, Stephan Urban & Stan F. J. van de Graaf

Scientific Reports | 7: 15307 | DOI:10.1038/s41598-017-15338-0

 

Intestinal FXR activation by pharmacological inhibition of the organic solute transporter α-β.

Sandra M.W. van de Wiel, D. Rudi de Waart, Ronald P.J. Oude Elferink and Stan F.J. van de Graaf. Cellular and Molecular Gastroenterology and Hepatology, 2017 Nov 28;5(3):223-237

 

 

2016

 

Immunoglobulin G4+ B-cell receptor clones distinguish immunoglobulin G 4-related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies.

Doorenspleet ME, Hubers LM, Culver EL, Maillette de Buy Wenniger LJ, Klarenbeek PL, Chapman RW, Baas F, van de Graaf SF, Verheij J, van Gulik TM, Barnes E, Beuers U, de Vries N.

Hepatology. 2016;64(2):501-7. doi: 10.1002/hep.28568. PMID: 27015613

 

Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis.

Van der Woerd WL, Wichers CG, Vestergaard AL, Andersen JP, Paulusma CC, Houwen RH, van de Graaf SF.

J Hepatol. 2016;64(6):1339-47. doi: 10.1016/j.jhep.2016.02.001. PMID: 26879107

 

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor

Sandra Van de Wiel, Maarten Merkx and Stan van de Graaf

Journal of Visualized Experiments, JoVE (http://www.jove.com/video/53659)

 

 

2015

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.

Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL.

J Cell Biol. 2015 Sep 28;210(7):1055-63. PMID: 26416959

 

Slijepcevic D, Kaufman C, Wichers CG, Gilglioni EH, Lempp FA, Duijst S, de Waart DR, Oude Elferink RP, Mier W, Stieger B, Beuers U, Urban S, Van de Graaf SF.

Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in Na(+) -taurocholate cotransporting polypeptide knockout mice. Hepatology. 2015 Jul;62(1):207-19] PubMed PMID: 25641256.

 

Van der Woerd WL, Mulder J, Pagani F, Beuers U, Houwen RH, Van de Graaf SF.

Analysis of aberrant pre-messenger RNA splicing resulting from mutations in ATP8B1 and efficient in vitro rescue by adapted U1 small nuclear RNA. Hepatology. 2015 Apr;61(4):1382-91. doi: 10.1002/hep.27620. Epub 2015 Feb 23. PubMed PMID: 25421123.

 

Hubers LM, Maillette de Buy Wenniger LJ, Doorenspleet ME, Klarenbeek PL,

Verheij J, Rauws EA, Van Gulik TM, Oude Elferink RP, Van de Graaf SF, de Vries N,

Beuers U. IgG4-Associated Cholangitis: A Comprehensive Review. Clin Rev Allergy

Immunol. 2015 Jun;48(2-3):198-206. doi: 10.1007/s12016-014-8430-2. PubMed PMID:

24958363.

 

Maroni L, Van de Graaf SF, Hohenester SD, Oude Elferink RP, Beuers U. Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease-a comprehensive review. Clin Rev Allergy Immunol. 2015 Jun;48(2-3):182-91. doi: 10.1007/s12016-014-8423-1. PubMed PMID: 24828903.

 

 

2014

Lindenburg LH, Malisauskas M, Sips T, Van Oppen L, Wijnands SP, Van de Graaf SF, Merkx M. Quantifying stickiness: thermodynamic characterization of intramolecular domain interactions to guide the design of förster resonance energy transfer sensors. Biochemistry. 2014 Oct 14;53(40):6370-81. doi: 10.1021/bi500433j. Epub 2014 Sep 26. PubMed PMID: 25216081.

 

Beuers U, Maillette de Buy Wenniger LJ, Doorenspleet M, Hubers L, Verheij J, Van Gulik T, Van de Graaf SF, de Vries N. IgG4-associated cholangitis. Dig Dis. 2014;32(5):605-8. doi: 10.1159/000360513. Epub 2014 Jul 14. Review. PubMed PMID: 25034294.

 

Autophagy - another piece of the puzzle towards understanding primary biliary cirrhosis? Van de Graaf S, Beuers U. Liver Int. 2014 Apr;34(4):481-3. doi: 10.1111/liv.12357. No abstract available. PMID: 24612169

 

2013

 

Van der Woerd WL, Van Haaften-Visser DY, Van de Graaf SF, Férec C, Masson E, Stapelbroek JM, Bugert P, Witt H, Houwen RH. Mutational analysis of ATP8B1 in patients with chronic pancreatitis. PLoS One. 2013 Nov 19;8(11):e80553. doi: 10.1371/journal.pone.0080553. eCollection 2013. PubMed PMID: 24260417; PubMed Central PMCID: PMC3834041.

 

Gao Y, Koppen A, Rakhshandehroo M, Tasdelen I, Van de Graaf SF, Van Loosdregt J, Van Beekum O, Hamers N, Van Leenen D, Berkers CR, Berger R, Holstege FC, Coffer PJ, Brenkman AB, Ovaa H, Kalkhoven E. Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60. Nat Commun. 2013;4:2656. doi: 10.1038/ncomms3656. PubMed PMID: 24141283.

 

Van der Velden LM, Golynskiy MV, Bijsmans IT, Van Mil SW, Klomp LW, Merkx M, Van de Graaf SF. Monitoring bile acid transport in single living cells using a genetically encoded Förster resonance energy transfer sensor. Hepatology. 2013 Feb;57(2):740-52. doi: 10.1002/hep.26012. Epub 2013 Jan 8. PubMed PMID: 22899095.

 

2012

 

Schipper HS, Rakhshandehroo M, Van de Graaf SF, Venken K, Koppen A, Stienstra R, Prop S, Meerding J, Hamers N, Besra G, Boon L, Nieuwenhuis EE, Elewaut D, Prakken B, Kersten S, Boes M, Kalkhoven E. Natural killer T cells in adipose tissue prevent insulin resistance. J Clin Invest. 2012 Sep;122(9):3343-54. doi: 10.1172/JCI62739. Epub 2012 Aug 6. PubMed PMID: 22863618; PubMed Central PMCID:

PMC3428087.

 

Bijsmans IT, Bouwmeester RA, Geyer J, Faber KN, Van de Graaf SF. Homo- and hetero-dimeric architecture of the human liver Na⁺-dependent taurocholate co-transporting protein. Biochem J. 2012 Feb 1;441(3):1007-15. doi: 10.1042/BJ20111234. PubMed PMID: 22029531.

 

 

2010

Van der Woerd WL, Van Mil SW, Stapelbroek JM, Klomp LW, Van de Graaf SF, Houwen RH. Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy. Best Pract Res Clin Gastroenterol. 2010 Oct;24(5):541-53. doi: 10.1016/j.bpg.2010.07.010. Review. PubMed PMID: 20955958.

 

Van der Velden LM, Wichers CG, Van Breevoort AE, Coleman JA, Molday RS, Berger R, Klomp LW, Van de Graaf SF. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. J Biol Chem. 2010 Dec 17;285(51):40088-96. doi: 10.1074/jbc.M110.139006. Epub 2010 Oct 14. PubMed PMID: 20947505; PubMed Central PMCID: PMC3000991.

 

Van der Velden LM, Van de Graaf SF, Klomp LW. Biochemical and cellular functions of P4 ATPases. Biochem J. 2010 Oct 1;431(1):1-11. doi: 10.1042/BJ20100644. Review. PubMed PMID: 20836764.

 

Van der Velden LM, Stapelbroek JM, Krieger E, Van den Berghe PV, Berger R, Verhulst PM, Holthuis JC, Houwen RH, Klomp LW, Van de Graaf SF. Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate. Hepatology. 2010 Jan;51(1):286-96. doi: 10.1002/hep.23268. PubMed PMID: 19918981.

 

2009

 

Van den Berghe PV, Stapelbroek JM, Krieger E, de Bie P, Van de Graaf SF, de Groot RE, Van Beurden E, Spijker E, Houwen RH, Berger R, Klomp LW. Reduced expression of ATP7B affected by Wilson disease-causing mutations is rescued by pharmacological folding chaperones 4-phenylbutyrate and curcumin. Hepatology. 2009 Dec;50(6):1783-95. doi: 10.1002/hep.23209. PubMed PMID: 19937698.

 

Schoeber JP, Van de Graaf SF, Lee KP, Wittgen HG, Hoenderop JG, Bindels RJ. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296(1):F204-11. doi: 10.1152/ajprenal.90473.2008. Epub 2008 Oct 8. PubMed PMID: 18842822.

 

2008 and before

 

Van de Graaf SF, Rescher U, Hoenderop JG, Verkaart S, Bindels RJ, Gerke V. TRPV5 is internalized via clathrin-dependent endocytosis to enter a Ca2+-controlled recycling pathway. J Biol Chem. 2008 Feb 15;283(7):4077-86. Epub 2007 Dec 12. PubMed PMID: 18077461.

 

Van de Graaf SF, Bindels RJ, Hoenderop JG. Physiology of epithelial Ca2+ and Mg2+ transport. Rev Physiol Biochem Pharmacol. 2007;158:77-160. Review. PubMed PMID: 17729442.

 

 

Van de Graaf SF, Hoenderop JG, Bindels RJ. Regulation of TRPV5 and TRPV6 by associated proteins. Am J Physiol Renal Physiol. 2006 Jun;290(6):F1295-302. Review. PubMed PMID: 16682485.

 

Van de Graaf SF, Hoenderop JG, Van der Kemp AW, Gisler SM, Bindels RJ. Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine-and kidney-enriched PDZ protein NHERF4. Pflugers Arch. 2006 Jul;452(4):407-17. Epub 2006 Mar 25. PubMed PMID: 16565876.

 

Van de Graaf SF, Van der Kemp AW, Van den Berg D, Van Oorschot M, HoenderopJG, Bindels RJ. Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity. J Am Soc Nephrol. 2006 Jan;17(1):26-30. PubMed PMID: 16380433.

 

Van de Graaf SF, Chang Q, Mensenkamp AR, Hoenderop JG, Bindels RJ. Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane. Mol Cell Biol. 2006 Jan;26(1):303-12. PubMed PMID: 16354700; PubMed Central PMCID: PMC1317621.

 

den Dekker E, Schoeber J, Topala CN, Van de Graaf SF, Hoenderop JG, Bindels RJ. Characterization of a Madin-Darby canine kidney cell line stably expressing TRPV5. Pflugers Arch. 2005 Jul;450(4):236-44. Epub 2005 May 28. PubMed PMID: 15924239.

 

Palmada M, Poppendieck S, Embark HM, Van de Graaf SF, Boehmer C, Bindels RJ, Lang F. Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1. Cell Physiol Biochem. 2005;15(1-4):175-82. PubMed PMID: 15665527.

 

Chang Q, Gyftogianni E, Van de Graaf SF, Hoefs S, Weidema FA, Bindels RJ, Hoenderop JG. Molecular determinants in TRPV5 channel assembly. J Biol Chem. 2004 Dec 24;279(52):54304-11. Epub 2004 Oct 15. PubMed PMID: 15489237.

 

Embark HM, Setiawan I, Poppendieck S, Van de Graaf SF, Boehmer C, Palmada M, Wieder T, Gerstberger R, Cohen P, Yun CC, Bindels RJ, Lang F. Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes. Cell Physiol Biochem. 2004;14(4-6):203-12. PubMed PMID: 15319523.

 

Van de Graaf SF, Boullart I, Hoenderop JG, Bindels RJ. Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):303-8. Review. PubMed PMID: 15225790.

 

Van de Graaf SF, Hoenderop JG, Gkika D, Lamers D, Prenen J, Rescher U, Gerke V, Staub O, Nilius B, Bindels RJ. Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J. 2003 Apr 1;22(7):1478-87. PubMed PMID: 12660155; PubMed Central PMCID: PMC152906.

 

Danahay H, Withey L, Poll CT, Van de Graaf SF, Bridges RJ. Protease-activated receptor-2-mediated inhibition of ion transport in human bronchial epithelial cells. Am J Physiol Cell Physiol. 2001 Jun;280(6):C1455-64. PubMed PMID:11350741.

 

Hoenderop JG, Van der Kemp AW, Hartog A, Van de Graaf SF, Van Os CH, Willems PH, Bindels RJ. Molecular identification of the apical Ca2+ channel in 1,25-dihydroxyvitamin D3-responsive epithelia. J Biol Chem. 1999 Mar26;274(13):8375-8. PubMed PMID: 10085067.